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Effect of low-fat vs low-carbohydrate diet on month weight loss in overweight adults and the association with genotype pattern or insulin secretion the DIETFITS randomized clinical trial. While not harmful for most adults, this type of diet may not be suitable for those with diabetes or insulin resistance. Low carbohydrate: Quick weight loss but long-term results vary Eating carbohydrates — especially highly processed ones like white bread and white rice — quickly boosts blood sugar, which triggers an outpouring of insulin from the pancreas. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. Am J Epidemiol.